How Does Cialis (Tadalafil) Affect Blood Circulation and Cause Erections?

Cialis’ active ingredient Tadalafil stands for a PDE5 inhibitor of the so-called “new generation” that was invented less than 15 years ago. Acting selectively, this component influences the blood stream and alters its chemical composition. The main thrust of the inhibitor is to reduce the amount of nitrogen oxide. This  new-gen inhibitors (V type) is capable of acting subtly by affecting only nitrogen oxide molecules and without affecting the other blood cells.

How does Cialis (Tadalafil) get into bloodstream?

Thus, Tadalafil increases the amount of blood flowing to male sexual organs than helps initiate a natural erection. Tadalafil acts only when a man experiencing a natural sexual arousal. When a sexual act is completed with normal ejaculation, a penis itself is usually restored and returned to its normal state. In a healthy body everything happens naturally, without any chemical aphrodisiacs. In other words, Cialis works only on natural mechanisms in a body responsible for erection’s process. It is a priceless quality and because of this many men recognize it the best way to prolong an active sex life.

If we approach the issue from the scientific point of view, an ability to study violations of erection in men have shown that the main component of blood that can reduce the potency is nitric oxide. It is a chemical that accumulates in the smooth muscles of a body, so being able to cause cramps in the calf muscles and even lead to a cardiovascular disease. It is this component in excess is in blood of some men is most often the cause of reducing a penis’ ability to get an erection and it as does not affect sexual performance of a man with the point of view of psychology. When being in blood of nitrogen oxide cannot simply allow the smooth muscle of a penis to activate blood flow, thus an erection does not occur or it will be very weak.

When Tadalafil is getting into the blood plasma that stimulates increased blood flow to a penile area. At the same time it helps to start the natural mechanism of erection. For this purpose, blood gets increased with the levels of released cyclic guanosine monophosphate. In healthy men this process starts automatically after sexual stimulation. With erectile dysfunction this process degrades under the influence of cGMP PDE-5 enzyme. Tadalafil blocks the action of phosphodiesterase enzyme, by filling the cavernous bodies of a penis with blood. For an erection of such type it is necessary tactile or visual sexual stimulation.

How long does Tadalafil stay in blood?

One of the key features of Cialis is that Tadalafil’s very rapidly absorbed and then completely eliminated from a body (mainly with feces). Metabolism of the active substance is carried by hepatic enzyme CYP3A4.

Tadalafil takes effect within 20-30 seconds after contact with blood. The effect usually appears after 15 minutes. Various factors, such as stress or any abnormal physical condition may delay the onset of action. Therefore it is recommended to take one Cialis pill about an hour before a planned sexual activity. The drug action’s time is 24-48 hrs (usually 36 hours).

Pharmacological effects of dissolved in blood Cialis

When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 with Tadalafil leads to increased levels of cGMP in the cavernous body of the penis. The result is relaxation of smooth muscles of arteries and the increased blood flow to penile issues that causes erections.

Tadalafil for healthy individuals does not cause significant changes in systolic and diastolic blood pressure compared with placebo in the prone position (meaning maximum decreased blood pressure of 1.6/0.8 mm Hg, respectively) and standing (meaning maximum decreased blood pressure of 0.2/4.6 mm Hg .st. respectively). Tadalafil does not cause significant changes in a heart rate unlike Viagra.

Tadalafil does not cause changes in the recognition of eye color (blue/green), due to its low affinity for PDE6.

Before you start taking Cilais or Generic Cialis, you need to learn more about possible drug interactions and other warnings. This information is available here: https://www.canadianhealthmall.com/generic-cialis

In order to assess the impact of Tadalafil with daily intake spermatogenesis the few studies in the United States have been conducted. None of studies have observed undesired effects on sperm morphology and motility. In one study there is showed the reduction in the average sperm concentration as compared to placebo’s clinical trials. Reduced sperm concentration was associated with a higher frequency of ejaculation. Moreover, Tadalafil does not cause undesirable changes of testosterone, LH and FSH in blood plasma, as compared to placebo.

These and other unknown facts about Cialis and Tadalafil can be found in the unbiased and interesting reviews made by the researches and experts of Canadian Pharmacy.